Capn3^tm1Jsb
Targeted Allele Detail

Summary

• Symbol: Capn3^tm1Jsb
• Name: calpain 3; targeted mutation 1, Jacques S Beckmann
• MGI ID: MGI:2177929
• Synonyms: CAPN3^-, Capn3^tm2.1Gnt
• Gene: Capn3 Location: Chr2:120294074-120335400 bp, + strand Genetic Position: Chr2, 60.31 cM
• Alliance: Capn3^tm1Jsb page

Dystrophic muscle in Capn3^tm1Jsb/Capn3^tm1Jsb mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66862
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 2 and 3 was replaced by a neomycin selection cassette. Western blot analysis on muscle extracts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:66862)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Capn3 Mutation: 49 strains or lines available

References

• Original: J:66862 Richard I, et al., Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice. J Cell Biol. 2000 Dec 25;151(7):1583-90
• All: 9 reference(s)