Wnt2^tm1Bjw
Targeted Allele Detail

Summary

• Symbol: Wnt2^tm1Bjw
• Name: wingless-type MMTV integration site family, member 2; targeted mutation 1, Brandon J Wainwright
• MGI ID: MGI:2177935
• Gene: Wnt2 Location: Chr6:17988939-18030584 bp, - strand Genetic Position: Chr6, 8.08 cM, cytoband A2-A3.1
• Alliance: Wnt2^tm1Bjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36835
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 3. RT-PCR analysis in RNA derived from lung and heart demonstrated that aberrant trancripts were made from this allele, but none are expected to encode a functional protein. (J:36835)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt2 Mutation: 26 strains or lines available

References

• Original: J:36835 Monkley SJ, et al., Targeted disruption of the Wnt2 gene results in placentation defects. Development. 1996 Nov;122(11):3343-53
• All: 3 reference(s)