Pin1^tm1Tuc
Targeted Allele Detail

Summary

• Symbol: Pin1^tm1Tuc
• Name: peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1; targeted mutation 1, Takafumi Uchida
• MGI ID: MGI:2177943
• Synonyms: Pin1-
• Gene: Pin1 Location: Chr9:20563335-20575008 bp, + strand Genetic Position: Chr9, 7.6 cM
• Alliance: Pin1^tm1Tuc page

Reduced body weight and testicular atrophy in Pin1^tm1Tuc/Pin1^tm1Tuc mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58734
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1-4, which contain the entire coding sequence of the gene. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:58734)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pin1 Mutation: 19 strains or lines available

References

• Original: J:58734 Fujimori F, et al., Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest. Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63
• All: 72 reference(s)