Etv6^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Etv6^tm1Sho
• Name: ets variant 6; targeted mutation 1, Stuart H Orkin
• MGI ID: MGI:2177950
• Synonyms: TEL -
• Gene: Etv6 Location: Chr6:134012663-134247121 bp, + strand Genetic Position: Chr6, 64.58 cM, cytoband G2
• Alliance: Etv6^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42409
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a DNA segment that contains exons coding for the DNA-binding domain. Northern blot and RT-PCR analysis on RNA derived from double-targeted ES cells demonstrated that no detectable transcript was produced from this allele. (J:42409)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv6 Mutation: 144 strains or lines available

References

• Original: J:42409 Wang LC, et al., Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997 Jul 16;16(14):4374-83
• All: 2 reference(s)