Srd5a2^tm1Mahe
Targeted Allele Detail

Summary

• Symbol: Srd5a2^tm1Mahe
• Name: steroid 5 alpha-reductase 2; targeted mutation 1, Mala Mahendroo
• MGI ID: MGI:2178039
• Synonyms: 2KO
• Gene: Srd5a2 Location: Chr17:74323950-74354911 bp, - strand Genetic Position: Chr17, 45.39 cM, cytoband E2
• Alliance: Srd5a2^tm1Mahe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72807
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic segment encompassing a portion of intron 1 through a portion of exon 3. Activity assays demonstrated the loss of protein function in homozygous mice. (J:72807)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srd5a2 Mutation: 17 strains or lines available

Notes

ES cell line = I1C.

References

• Original: J:72807 Mahendroo MS, et al., Unexpected virilization in male mice lacking steroid 5alpha-reductase enzymes. Endocrinology. 2001 Nov;142(11):4652-62
• All: 5 reference(s)