Krt18^tm1Tmm
Targeted Allele Detail

Summary

• Symbol: Krt18^tm1Tmm
• Name: keratin 18; targeted mutation 1, Thomas M Magin
• MGI ID: MGI:2178045
• Synonyms: K18^-, K18 null
• Gene: Krt18 Location: Chr15:101936651-101940461 bp, + strand Genetic Position: Chr15, 57.22 cM, cytoband F3
• Alliance: Krt18^tm1Tmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46610
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• An HPRT minigene replaced most of exon 1, intron 1 and exon 2. (J:46610)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Krt18 Mutation: 28 strains or lines available

References

• Original: J:46610 Magin TM, et al., Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol. 1998 Mar 23;140(6):1441-51
• All: 15 reference(s)