Gria1^tm1Rsp
Targeted Allele Detail

Summary

• Symbol: Gria1^tm1Rsp
• Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 1, Rolf Sprengel
• MGI ID: MGI:2178057
• Synonyms: GluA1-, GluR1-, GluR-A-, GluRA-
• Gene: Gria1 Location: Chr11:56902342-57221070 bp, + strand Genetic Position: Chr11, 34.51 cM
• Alliance: Gria1^tm1Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55695
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was inserted into intron 10 and a loxP flanked neomycin selection cassette was inserted into exon 11. The loxP-flanked sequences were deleted in ES cells by transient Cre expression prior to the production of chimeric mice. The final heritable allele contains a single loxP site replacing exon 11 and flanking intronic sequences. Immunohistochemistry experiments confirmed that no detectable protein is expressed from this allele. (J:55695)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria1 Mutation: 65 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Schizoaffective Disorder (J:167264).

References

• Original: J:55695 Zamanillo D, et al., Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning [see comments]. Science. 1999 Jun 11;284(5421):1805-11
• All: 62 reference(s)