Adarb1^tm1Phs
Targeted Allele Detail

Summary

• Symbol: Adarb1^tm1Phs
• Name: adenosine deaminase, RNA-specific, B1; targeted mutation 1, Peter H Seeburg
• MGI ID: MGI:2178079
• Synonyms: ADAR2 -
• Gene: Adarb1 Location: Chr10:77126560-77254104 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Adarb1^tm1Phs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63273
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance gene replaced most of exon 4, which encodes domains essential for protein function. RNase protection assays demonstrated that a mutant transcript was produced from this allele at low levels that may express a functionally inactive protein with intact RNA binding domains. (J:63273)

Expression

In Mice Carrying this Mutation:

6 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adarb1 Mutation: 37 strains or lines available

References

• Original: J:63273 Higuchi M, et al., Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature. 2000 Jul 6;406(6791):78-81
• All: 19 reference(s)