Grin1^tm2Phs
Targeted Allele Detail

Summary

• Symbol: Grin1^tm2Phs
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 2, Peter H Seeburg
• MGI ID: MGI:2178083
• Synonyms: NR1^Rneo
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm2Phs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75497
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations were introduced that altered codon 598 in exon 15 from one encoding asparagine to one encoding arginine (N598R). Expression is silenced by the presence in intron 18 of a loxP-flanked neomycin resistance cassette, whose removal by Cre recombinase will activate the mutant allele. (J:75497)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 66 strains or lines available

References

• Original: J:75497 Single FN, et al., Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R). J Neurosci. 2000 Apr 1;20(7):2558-66
• All: 3 reference(s)