Rims1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Rims1^tm1Sud
• Name: regulating synaptic membrane exocytosis 1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2178099
• Synonyms: RIM1alpha-, Rim1alpha^mt
• Gene: Rims1 Location: Chr1:22356475-22845203 bp, - strand Genetic Position: Chr1, 8.54 cM, cytoband A5
• Alliance: Rims1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73900
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the first coding exon, which encodes the translation initiation site and 55 conserved N-terminal residues. Immunoblot analysis using antibody to the N-terminal zinc finger domain did not detect protein. (J:73900)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rims1 Mutation: 88 strains or lines available

References

• Original: J:73900 Schoch S, et al., RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature. 2002 Jan 17;415(6869):321-6
• All: 23 reference(s)