Tcf3^tm1Wein
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm1Wein
• Name: transcription factor 3; targeted mutation 1, Harold Weintraub
• MGI ID: MGI:2178112
• Synonyms: E2A^-, E2A^deltabHLH
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm1Wein page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22134
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced two adjacent exons that encode alternative basic-helix-loop-helix transcription factors E12 and E47. (J:22134)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 43 strains or lines available

References

• Original: J:22134 Zhuang Y, et al., The helix-loop-helix gene E2A is required for B cell formation. Cell. 1994 Dec 2;79(5):875-84
• All: 10 reference(s)