Tcf3^tm1Cmu
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm1Cmu
• Name: transcription factor 3; targeted mutation 1, Cornelis Murre
• MGI ID: MGI:2178119
• Synonyms: E2A-
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm1Cmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67011
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into the E12-specific exon disrupted the gene. RT-PCR studies of fetal liver and of lung from 5 week old mice detected trace amounts of E47-specific transcript in homozygous mutant mice. The authors predict that both gene products, E12 and E47, are inactivated in this allele. (J:67011)

Disease models

Expression

In Mice Carrying this Mutation:

48 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 43 strains or lines available

Notes

ES cell line = either E14 or E14-derived.

References

• Original: J:67011 Bain G, et al., E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 1994 Dec 2;79(5):885-92
• All: 16 reference(s)