Gria2^tm2Rsp
Targeted Allele Detail

Summary

• Symbol: Gria2^tm2Rsp
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 2, Rolf Sprengel
• MGI ID: MGI:2178121
• Synonyms: GluR-B^neo
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm2Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51845
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The editing site complementary sequence (ECS) in intron 11 was replaced with a loxP-flanked neomycin resistance cassette. Northern blot and in situ hybridization analysis demonstrated that low levels of unedited transcripts were produced from this allele. (J:51845)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 79 strains or lines available

References

• Original: J:51845 Feldmeyer D, et al., Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci. 1999 Jan;2(1):57-64
• All: 6 reference(s)