Gria2^tm1Phs
Targeted Allele Detail

Summary

• Symbol: Gria2^tm1Phs
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1, Peter H Seeburg
• MGI ID: MGI:2178124
• Synonyms: GluR-B^Rneo
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm1Phs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50929
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations were introduced that altered the Q/R edited codon from one encoding glutamate to one encoding arginine (R). A loxP flanked neomycin resistance cassette was inserted into intron 11, 5' to the ECS site. Gria2 (GluR-B) gene expression is reduced by 30% compared to wild-type. (J:50929)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 79 strains or lines available

References

• Original: J:50929 Kask K, et al., The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13777-82
• All: 1 reference(s)