Serpinc1^tm1Sai
Targeted Allele Detail

Summary

• Symbol: Serpinc1^tm1Sai
• Name: serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; targeted mutation 1, Hidehiko Saito
• MGI ID: MGI:2178128
• Synonyms: AT-, ATIII^-
• Gene: Serpinc1 Location: Chr1:160806153-160830113 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Serpinc1^tm1Sai page

Subcutaneous hemorrhage in Serpinc1^tm1Sai/Serpinc1^tm1Sai mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65092
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2 and flanking intronic sequences. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele, and western blot analysis on liver lysates confirmed that no protein was expressed from this allele. (J:65092)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpinc1 Mutation: 28 strains or lines available

References

• Original: J:65092 Ishiguro K, et al., Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest. 2000 Oct;106(7):873-8
• All: 4 reference(s)