Map2k1^{Gt(ROSABetageo)J2Chrn}
Gene trapped Allele Detail

Summary

• Symbol: Map2k1^{Gt(ROSABetageo)J2Chrn}
• Name: mitogen-activated protein kinase kinase 1; gene trap J2, Jean Charron
• MGI ID: MGI:2178132
• Synonyms: Map2k1^-, mek1 -
• Gene: Map2k1 Location: Chr9:64093066-64160887 bp, - strand Genetic Position: Chr9, 34.55 cM
• Alliance: Map2k1^{Gt(ROSABetageo)J2Chrn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54197
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted into intron 1, causing the expression of an abnormal transcript that is interrupted after codon 26. Western blot analysis on extracts of embryos or embryonic fibroblasts derived from homozygous embryos confirmed that no detectable protein was expressed from this allele. (J:54197)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k1 Mutation: 94 strains or lines available

References

• Original: J:54197 Giroux S, et al., Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol. 1999 Apr 8;9(7):369-72
• All: 4 reference(s)