Map3k3^tm1Bisu
Targeted Allele Detail

Summary

• Symbol: Map3k3^tm1Bisu
• Name: mitogen-activated protein kinase kinase kinase 3; targeted mutation 1, Bing Su
• MGI ID: MGI:2178133
• Synonyms: Mekk3-
• Gene: Map3k3 Location: Chr11:105975439-106046272 bp, + strand Genetic Position: Chr11, 68.89 cM
• Alliance: Map3k3^tm1Bisu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60748
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene followed by a neomycin resistance cassette replaced part of the coding sequences of the gene. (J:60748)

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k3 Mutation: 27 strains or lines available

References

• Original: J:60748 Yang J, et al., Mekk3 is essential for early embryonic cardiovascular development. Nat Genet. 2000 Mar;24(3):309-13
• All: 8 reference(s)