Tcf3^tm2Cmu
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm2Cmu
• Name: transcription factor 3; targeted mutation 2, Cornelis Murre
• MGI ID: MGI:2178143
• Synonyms: E47-
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm2Cmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into the E47-specific HLH exon disrupted the gene. Western blot analyses of thymus from homozygous mutant mice did not detect E47 protein, and detected E12 protein at levels that were at least 5-fold lower than wild-type. (J:38711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 43 strains or lines available

Notes

ES cell line was E14, or was E14-derived.

References

• Original: J:38711 Bain G, et al., Both E12 and E47 allow commitment to the B cell lineage. Immunity. 1997 Feb;6(2):145-54
• All: 19 reference(s)