Mycn^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Mycn^tm1Fwa
• Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:2178216
• Synonyms: N-myc^-
• Gene: Mycn Location: Chr12:12986094-12991837 bp, - strand Genetic Position: Chr12, 6.14 cM, cytoband A3-B
• Alliance: Mycn^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3413
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced part of exon 2. Northern blot analysis confirmed absence of wild-type transcripts in homozygous mutant embryos at E10.5. (J:3413)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycn Mutation: 25 strains or lines available

References

• Original: J:3413 Charron J, et al., Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 1992 Dec;6(12A):2248-57
• All: 2 reference(s)