Mycn^tm1Jrt
Targeted Allele Detail

Summary

• Symbol: Mycn^tm1Jrt
• Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1, Janet Rossant
• MGI ID: MGI:2178220
• Synonyms: N-myc^9a
• Gene: Mycn Location: Chr12:12986094-12991837 bp, - strand Genetic Position: Chr12, 6.14 cM, cytoband A3-B
• Alliance: Mycn^tm1Jrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:973
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector inserted into intron 1, instead of replacing exon 2 by homologous recombination. Northern blot analysis on RNA derived from embryonic brain, lung and kidney demonstrated that a reduced level of normal transcript was produced from this allele, and that the amounts expressed were tissue dependent. (J:973)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycn Mutation: 25 strains or lines available

Notes

Hypomorphic allele.

References

• Original: J:973 Moens CB, et al., A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes Dev. 1992 May;6(5):691-704
• All: 4 reference(s)