About   Help   FAQ
Mycntm1Jrt
Targeted Allele Detail
Summary
Symbol: Mycntm1Jrt
Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1, Janet Rossant
MGI ID: MGI:2178220
Synonyms: N-myc9a
Gene: Mycn  Location: Chr12:12986094-12991837 bp, - strand  Genetic Position: Chr12, 6.14 cM, cytoband A3-B
Alliance: Mycntm1Jrt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:973
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector inserted into intron 1, instead of replacing exon 2 by homologous recombination. Northern blot analysis on RNA derived from embryonic brain, lung and kidney demonstrated that a reduced level of normal transcript was produced from this allele, and that the amounts expressed were tissue dependent. (J:973)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mycn Mutation:  25 strains or lines available
Notes
Hypomorphic allele.
References
Original:  J:973 Moens CB, et al., A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes Dev. 1992 May;6(5):691-704
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory