Foxl1^tm1Khk
Targeted Allele Detail

Summary

• Symbol: Foxl1^tm1Khk
• Name: forkhead box L1; targeted mutation 1, Klaus H Kaestner
• MGI ID: MGI:2178230
• Synonyms: Fkh6-, Foxl1 null
• Gene: Foxl1 Location: Chr8:121854679-121857383 bp, + strand Genetic Position: Chr8, 70.34 cM
• Alliance: Foxl1^tm1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41235
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene followed by a neomycin resistance gene replaced an 860 bp fragment of the gene that contained the sequences encoding the winged helix DNA binding domain and the carboxy terminus of the protein. RNase protection assays demonstrated that no transcript was expressed from this allele in homozygous mice. (J:41235)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxl1 Mutation: 12 strains or lines available

References

• Original: J:41235 Kaestner KH, et al., The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev. 1997 Jun 15;11(12):1583-95
• All: 5 reference(s)