Myc^{tm1.1(Nmyc1)Fwa}
Targeted Allele Detail

Summary

• Symbol: Myc^{tm1.1(Nmyc1)Fwa}
• Name: myelocytomatosis oncogene; targeted mutation 1.1, Frederick W Alt
• MGI ID: MGI:2178232
• Synonyms: c-myc^N
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^{tm1.1(Nmyc1)Fwa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62573
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire second exon, the coding portion of the third exon and the intervening intron were replaced with the analogous sequences from Nmyc1 gene. A loxP flanked neomycin selection cassette was removed by mating mice carrying this allele to mice expressing Cre recombinase under the control of an EIIa promoter. Northern blot analysis confirmed the expression of a fusion transcript under the control of the endogenous promoter. (J:62573)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:62573 Malynn BA, et al., N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 1;14(11):1390-9
• All: 3 reference(s)