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Myctm1.1(Nmyc1)Fwa
Targeted Allele Detail
Summary
Symbol: Myctm1.1(Nmyc1)Fwa
Name: myelocytomatosis oncogene; targeted mutation 1.1, Frederick W Alt
MGI ID: MGI:2178232
Synonyms: c-mycN
Gene: Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance: Myctm1.1(Nmyc1)Fwa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62573
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire second exon, the coding portion of the third exon and the intervening intron were replaced with the analogous sequences from Nmyc1 gene. A loxP flanked neomycin selection cassette was removed by mating mice carrying this allele to mice expressing Cre recombinase under the control of an EIIa promoter. Northern blot analysis confirmed the expression of a fusion transcript under the control of the endogenous promoter. (J:62573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:  43 strains or lines available
References
Original:  J:62573 Malynn BA, et al., N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 1;14(11):1390-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory