Myc^tm2Fwa
Targeted Allele Detail

Summary

• Symbol: Myc^tm2Fwa
• Name: myelocytomatosis oncogene; targeted mutation 2, Frederick W Alt
• MGI ID: MGI:2178233
• Synonyms: c-myc^fl, MYC^fl, Myc^flox, Myclox
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm2Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67222
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 1 and a loxP-flanked neomycin selection cassette was inserted 3' to exon 3. The neomycin cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. (J:67222)

Expression

In Mice Carrying this Mutation:	103 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 2 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:67222 de Alboran IM, et al., Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001 Jan;14(1):45-55
• All: 128 reference(s)