Bomd4^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Bomd4^C57BL/6
• Name: bone mineral density 4; C57BL/6
• MGI ID: MGI:2178275
• QTL: Bomd4 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 15.42 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased bone mineral density compared to DBA/2.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75820

18 BXD (B=C57BL/6, D=DBA/2) recombinant inbred (RI) strains were used to map QTLs associated with bone mineral density. Two sex-specific loci were identified on mouse Chromosome 2 and mouse Chromosome 7, and confirmed in a (C57BL/6 x DBA/2)F2 population. Bomd3 is a female specific locus mapping to Chromosome 2 near D2Mit94 at approximately 48 cM. DBA/2-derived alleles appear to confer increased bone mass in a dominant fashion at Bomd3. Bomd4 is a male specific locus and maps to Chromosome 7 near D7Mit114 at approximately 8 cM. DBA/2-derived alleles appear to confer increased bone mineral density in an additive or dominant fashion at Bomd4.

References

• Original: J:75820 Orwoll ES, et al., Gender specificity in the genetic determinants of peak bone mass. J Bone Miner Res. 2001 Nov;16(11):1962-71
• All: 1 reference(s)