Pde6b^atrd1
Chemically induced Allele Detail

Summary

• Symbol: Pde6b^atrd1
• Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; atypical retinal degeneration 1
• MGI ID: MGI:2178311
• Synonyms: Gena245, GENA 245, Pde6b^H620Q
• Gene: Pde6b Location: Chr5:108536239-108579609 bp, + strand Genetic Position: Chr5, 53.07 cM
• Alliance: Pde6b^atrd1 page

Mutation origin

• Strain of Origin: BALB/cAnN

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T1860A missense mutation in exon 15 resulted in a histidine to glutamine substitution at amino acid 620. (J:75964)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pde6b Mutation: 122 strains or lines available

References

• Original: J:75964 Thaung C, et al., Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet. 2002 Apr 1;11(7):755-67
• All: 14 reference(s)