Pde6b^rd1-2H
Chemically induced Allele Detail

Summary

• Symbol: Pde6b^rd1-2H
• Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; retinal degeneration 1, 2 Harwell
• MGI ID: MGI:2178318
• Synonyms: Gena308, GENA 308
• Gene: Pde6b Location: Chr5:108536239-108579609 bp, + strand Genetic Position: Chr5, 53.07 cM
• Alliance: Pde6b^rd1-2H page

Mutation origin

• Strain of Origin: (C3H/HeN x BALB/cAnN)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A nonsense mutation in exon 21 (C2395T) caused a premature stop codon at the arginine at position 799. (J:75964)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Pde6b Mutation: 122 strains or lines available

References

• Original: J:75964 Thaung C, et al., Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet. 2002 Apr 1;11(7):755-67
• All: 2 reference(s)