F3^tm1Dco
Targeted Allele Detail

Summary

• Symbol: F3^tm1Dco
• Name: coagulation factor III; targeted mutation 1, Desire Collen
• MGI ID: MGI:2178434
• Synonyms: mF3^-, mTF^-, TF -
• Gene: F3 Location: Chr3:121517186-121528697 bp, + strand Genetic Position: Chr3, 52.94 cM
• Alliance: F3^tm1Dco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35120
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the first exon of the gene. Northern blot analysis on embryonic fibroblasts derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:35120)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F3 Mutation: 24 strains or lines available

References

• Original: J:35120 Carmeliet P, et al., Role of tissue factor in embryonic blood vessel development. Nature. 1996 Sep 5;383(6595):73-5
• All: 36 reference(s)