Agtr2^tm1Tin
Targeted Allele Detail

Summary

• Symbol: Agtr2^tm1Tin
• Name: angiotensin II receptor, type 2; targeted mutation 1, Tadashi Inagami
• MGI ID: MGI:2178475
• Synonyms: AT2-, AT2 KO, AT2-KO, AT2R^-, AT2^tm1ti
• Gene: Agtr2 Location: ChrX:21350863-21355072 bp, + strand Genetic Position: ChrX, 16.71 cM
• Alliance: Agtr2^tm1Tin page

Enhanced bone mass in Agtr2^tm1Tin/Y mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29457
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a fragment of exon 3 containing most of the coding region of the gene. Northern blot analysis on RNA derived from E17 hemizygous male embryos or adult hemizygous male brain demonstrated that no transcript was expressed from this allele. (J:29457)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	29 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Agtr2^tm1Tin

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr2 Mutation: 11 strains or lines available

References

• Original: J:29457 Ichiki T, et al., Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995 Oct 26;377(6551):748-50
• All: 66 reference(s)