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Crhr2tm1Klee
Targeted Allele Detail
Summary
Symbol: Crhr2tm1Klee
Name: corticotropin releasing hormone receptor 2; targeted mutation 1, Kuo-Fen Lee
MGI ID: MGI:2178545
Synonyms: CRFR2 KO
Gene: Crhr2  Location: Chr6:55067034-55110001 bp, - strand  Genetic Position: Chr6, 27.33 cM
Alliance: Crhr2tm1Klee page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61484
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 10-12, which encode part of transmembrane domain 5, through the end of the transmembrane domain. Binding assays on sections of adult homozygous brain confirmed that no functional protein was expressed from this allele. (J:61484)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129S4/SvJae * C57BL/6
 
involves: 129S4/SvJae * C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
   
adipose tissue
decreased total body fat amount
decreased brown fat cell size
abnormal white fat cell morphology
abnormal adipose tissue physiology
behavior/neurological
abnormal food intake
behavioral despair
abnormal anxiety-related response
increased anxiety-related response
decreased vertical activity
cardiovascular system
abnormal blood vessel morphology
increased angiogenesis
abnormal systemic arterial blood pressure
hypertension
endocrine/exocrine glands
N
endocrine/exocrine gland phenotype
N N
decreased adrenal gland zona fasciculata size
adrenal gland atrophy
homeostasis/metabolism
homeostasis/metabolism phenotype
N
decreased circulating cholesterol level
decreased circulating free fatty acids level
decreased circulating triglyceride level
abnormal glucose homeostasis
increased insulin sensitivity
abnormal hormone level
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crhr2 Mutation:  35 strains or lines available
References
Original:  J:61484 Bale TL, et al., Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet. 2000 Apr;24(4):410-4
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory