Crhr2^tm1Klee
Targeted Allele Detail

Summary

• Symbol: Crhr2^tm1Klee
• Name: corticotropin releasing hormone receptor 2; targeted mutation 1, Kuo-Fen Lee
• MGI ID: MGI:2178545
• Synonyms: CRFR2 KO
• Gene: Crhr2 Location: Chr6:55067034-55110001 bp, - strand Genetic Position: Chr6, 27.33 cM
• Alliance: Crhr2^tm1Klee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61484
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 10-12, which encode part of transmembrane domain 5, through the end of the transmembrane domain. Binding assays on sections of adult homozygous brain confirmed that no functional protein was expressed from this allele. (J:61484)

Expression

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crhr2 Mutation: 35 strains or lines available

References

• Original: J:61484 Bale TL, et al., Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet. 2000 Apr;24(4):410-4
• All: 27 reference(s)