Crhr2tm1Klee
Targeted Allele Detail
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Symbol: |
Crhr2tm1Klee |
Name: |
corticotropin releasing hormone receptor 2; targeted mutation 1, Kuo-Fen Lee |
MGI ID: |
MGI:2178545 |
Synonyms: |
CRFR2 KO |
Gene: |
Crhr2 Location: Chr6:55067034-55110001 bp, - strand Genetic Position: Chr6, 27.33 cM
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Alliance: |
Crhr2tm1Klee page
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Germline Transmission: |
Earliest citation of germline transmission:
J:61484
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Parent Cell Line: |
AK7 (ES Cell)
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Strain of Origin: |
129S4/SvJaeSor
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 10-12, which encode part of transmembrane domain 5, through the end of the transmembrane domain. Binding assays on sections of adult homozygous brain confirmed that no functional protein was expressed from this allele.
(J:61484)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S4/SvJae * C57BL/6 | | | | involves: 129S4/SvJae * C57BL/6 | |
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Phenotypes: |
Affected Systems |
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adipose tissue
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√
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decreased total body fat amount
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√
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decreased brown fat cell size
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√
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abnormal white fat cell morphology
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√
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abnormal adipose tissue physiology
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√
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behavior/neurological
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√
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√
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abnormal food intake
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√
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behavioral despair
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√
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abnormal anxiety-related response
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√
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increased anxiety-related response
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√
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decreased vertical activity
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√
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cardiovascular system
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√
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abnormal blood vessel morphology
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√
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increased angiogenesis
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√
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abnormal systemic arterial blood pressure
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√
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hypertension
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√
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endocrine/exocrine glands
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N
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√
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endocrine/exocrine gland phenotype
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N
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N
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decreased adrenal gland zona fasciculata size
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√
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adrenal gland atrophy
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√
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homeostasis/metabolism
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√
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√
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homeostasis/metabolism phenotype
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N
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decreased circulating cholesterol level
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√
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decreased circulating free fatty acids level
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√
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decreased circulating triglyceride level
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√
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abnormal glucose homeostasis
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√
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increased insulin sensitivity
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√
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abnormal hormone level
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√
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Crhr2 Mutation: |
35 strains or lines available
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Original: |
J:61484 Bale TL, et al., Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet. 2000 Apr;24(4):410-4 |
All: |
27 reference(s) |
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