Ifi30^tm1Cres
Targeted Allele Detail

Summary

• Symbol: Ifi30^tm1Cres
• Name: interferon gamma inducible protein 30; targeted mutation 1, Peter Cresswell
• MGI ID: MGI:2178559
• Synonyms: GILT^-
• Gene: Ifi30 Location: Chr8:71215419-71219307 bp, - strand Genetic Position: Chr8, 34.15 cM
• Alliance: Ifi30^tm1Cres page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72708
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 though 7 were replaced with a neomycin resistance gene. Western analysis demonstrated a lack of protein in homozygous mutant animals in extracts from the lymph nodes, spleen, lung and muscle. Weak signals were detected in extracts from the kidney and liver. (J:72708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifi30 Mutation: 14 strains or lines available

References

• Original: J:72708 Maric M, et al., Defective Antigen Processing in GILT-Free Mice. Science. 2001 Nov 9;294(5545):1361-5
• All: 16 reference(s)