Cebpe^tm1Kgx
Targeted Allele Detail

Summary

• Symbol: Cebpe^tm1Kgx
• Name: CCAAT/enhancer binding protein epsilon; targeted mutation 1, Kleanthis G Xanthopoulos
• MGI ID: MGI:2178607
• Synonyms: C/EBPepsilon-
• Gene: Cebpe Location: Chr14:54947823-54949604 bp, - strand Genetic Position: Chr14, 27.9 cM
• Alliance: Cebpe^tm1Kgx page

Cebpe^tm1Kgx/Cebpe^tm1Kgx mice exhibit a variety of lesions associated with opportunistic bacetrial infections

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76024
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.2 kb genomic fragment containing 334 bp of sequence encoding the bZIP region was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from bone marrow cells demonstrated that no detectable transcript was expressed from this allele. (J:76024)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpe Mutation: 13 strains or lines available

References

• Original: J:76024 Yamanaka R, et al., Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13187-92
• All: 21 reference(s)