Ubr1^tm1Avar
Targeted Allele Detail

Summary

• Symbol: Ubr1^tm1Avar
• Name: ubiquitin protein ligase E3 component n-recognin 1; targeted mutation 1, Alexander Varshavsky
• MGI ID: MGI:2178612
• Synonyms: UBR1 -
• Gene: Ubr1 Location: Chr2:120690750-120801196 bp, - strand Genetic Position: Chr2, 60.37 cM
• Alliance: Ubr1^tm1Avar page

Abnormal development of the central nervous system in Ubr1^tm1Avar/Ubr1^tm1Avar Ubr2^tm1Ytkw/Ubr2^tm1Ytkw embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72859
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were replaced by a neo cassette. This coding sequence in this region is highly conserved between S.cerevisiae and mouse, and includes amino acids found to be essential for the type 1 and type 2 substrate binding site. (J:72859)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubr1 Mutation: 94 strains or lines available

References

• Original: J:72859 Kwon YT, et al., Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3alpha) of the N-End Rule Pathway. Mol Cell Biol. 2001 Dec;21(23):8007-21
• All: 7 reference(s)