Crhr2^tm1Mpsp
Targeted Allele Detail

Summary

• Symbol: Crhr2^tm1Mpsp
• Name: corticotropin releasing hormone receptor 2; targeted mutation 1, Mary P Stenzel-Poore
• MGI ID: MGI:2178619
• Synonyms: CRF2 KO
• Gene: Crhr2 Location: Chr6:55067034-55110001 bp, - strand Genetic Position: Chr6, 27.33 cM
• Alliance: Crhr2^tm1Mpsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61510
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons encoding transmembrane domains 3-5 and surrounding sequence were replaced with a neo cassette via homologous recombination. (J:61510)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crhr2 Mutation: 35 strains or lines available

References

• Original: J:61510 Coste SC, et al., Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet. 2000 Apr;24(4):403-9
• All: 16 reference(s)