Drd4^tm1Dkg
Targeted Allele Detail

Summary

• Symbol: Drd4^tm1Dkg
• Name: dopamine receptor D4; targeted mutation 1, David K Grandy
• MGI ID: MGI:2178631
• Synonyms: D4^-, D4KO, D4R -, Drd4^-
• Gene: Drd4 Location: Chr7:140871931-140874868 bp, + strand Genetic Position: Chr7, 86.6 cM
• Alliance: Drd4^tm1Dkg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43061
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2. RT-PCR analysis demonstrated that a mutated transcript was produced from this allele that spliced exon 1 to exon 3. This mutation causes a shift in the reading frame that is predicted to result in the production of a truncated protein. (J:43061)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd4 Mutation: 33 strains or lines available

References

• Original: J:43061 Rubinstein M, et al., Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell. 1997 Sep 19;90(6):991-1001
• All: 39 reference(s)