Nfib^tm1Hsch
Targeted Allele Detail

Summary

• Symbol: Nfib^tm1Hsch
• Name: nuclear factor I/B; targeted mutation 1, Heinrich Schrewe
• MGI ID: MGI:2178748
• Synonyms: Nfib^E2-lacZ
• Gene: Nfib Location: Chr4:82208410-82424988 bp, - strand Genetic Position: Chr4, 38.4 cM, cytoband C4-C6
• Alliance: Nfib^tm1Hsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75698
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ reporter gene was inserted in frame into the DNA binding domain of exon 2. A Nfib-lacZ fusion mRNA is generated containing only the first 11 codons of the Nfib gene. (J:75698)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfib Mutation: 91 strains or lines available

References

• Original: J:75698 Grunder A, et al., Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77
• All: 1 reference(s)