Otx2^tm4.1Sia
Targeted Allele Detail

Summary

• Symbol: Otx2^tm4.1Sia
• Name: orthodenticle homeobox 2; targeted mutation 4.1, Shinichi Aizawa
• MGI ID: MGI:2178753
• Synonyms: Otx2/flox, Otx2^flox
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm4.1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74631
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele is a derivative of Otx2^tm4Sia in which the neomycin resistance cassette was removed by crossing mice carrying the Otx2^tm4Sia allele to mice expressing Flp recombinase in the germline. The final allele carries a single frt site in place of the frt-flanked neomycin cassette. (J:74631)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:74631 Tian E, et al., Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002 Feb 15;242(2):204-23
• All: 16 reference(s)