Otx2^tm4.2Sia
Targeted Allele Detail

Summary

• Symbol: Otx2^tm4.2Sia
• Name: orthodenticle homeobox 2; targeted mutation 4.2, Shinichi Aizawa
• MGI ID: MGI:2178755
• Synonyms: Otx2^deltapro-ex1
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm4.2Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74631
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Otx2^tm4.1Sia in which the loxP-flanked sequences were removed by crossing mice carrying the Otx2^tm4.1Sia allele to mice expressing Cre recombinase in the germline [TgN(ACTB-Cre)2Mrt]. The final allele carries a single loxP site in place of the promoter and first exon of the gene, and a single frt site in place of the frt-flanked neomycin cassette. (J:74631)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:74631 Tian E, et al., Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002 Feb 15;242(2):204-23
• All: 1 reference(s)