Npr1^tm1Gar
Targeted Allele Detail

Summary

• Symbol: Npr1^tm1Gar
• Name: natriuretic peptide receptor 1; targeted mutation 1, David L Garbers
• MGI ID: MGI:2178776
• Synonyms: GC-A^-, GC-A KO
• Gene: Npr1 Location: Chr3:90357898-90373173 bp, - strand Genetic Position: Chr3, 39.23 cM
• Alliance: Npr1^tm1Gar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30007
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into exon 4, which encodes part of the extra-cellular putative ligand-binding domain, disrupted the gene. Stable, wild-type size transcript was not detected in liver or kidney from homozygous mutant mice. (J:30007)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr1 Mutation: 60 strains or lines available

References

• Original: J:30007 Lopez MJ, et al., Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide. Nature. 1995 Nov 2;378(6552):65-8
• All: 38 reference(s)