Casp3^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Casp3^tm1Mak
• Name: caspase 3; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2178778
• Synonyms: Casp3^-, CPP32^ex3-
• Gene: Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
• Alliance: Casp3^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74972
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 3 was replaced with a neomycin selection cassette. Western blot analysis on lysates derived from doubly targeted ES cells confirmed that no detectable protein was produced from this allele. (J:74972)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp3 Mutation: 33 strains or lines available

References

• Original: J:74972 Woo M, et al., Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 1998 Mar 15;12(6):806-19
• All: 25 reference(s)