B4galt1^tm1Shur
Targeted Allele Detail

Summary

• Symbol: B4galt1^tm1Shur
• Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; targeted mutation 1, Barry D Shur
• MGI ID: MGI:2178779
• Synonyms: GalTase-null, gt -, total gt-
• Gene: B4galt1 Location: Chr4:40804602-40854005 bp, - strand Genetic Position: Chr4, 20.46 cM
• Alliance: B4galt1^tm1Shur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37846
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt 1.9kb of sequence of exon 1, which encodes all of the cytoplasmic and transmembran domains as well as part of the extracellular region. Neither the long or short isoform of the encoded protein is expressed from this allele. (J:37846)

Disease models

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any B4galt1 Mutation: 43 strains or lines available

References

• Original: J:37846 Lu Q, et al., Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality. Dev Biol. 1997 Jan 15;181(2):257-67
• All: 7 reference(s)