Mad2l1^tm1Sorg
Targeted Allele Detail

Summary

• Symbol: Mad2l1^tm1Sorg
• Name: MAD2 mitotic arrest deficient-like 1; targeted mutation 1, Peter K Sorger
• MGI ID: MGI:2178781
• Synonyms: Mad2^-
• Gene: Mad2l1 Location: Chr6:66512205-66518091 bp, + strand Genetic Position: Chr6, 30.56 cM
• Alliance: Mad2l1^tm1Sorg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62829
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin resistance cassette replaced the entire coding region. (J:62829)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mad2l1^tm1Sorg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mad2l1 Mutation: 15 strains or lines available

References

• Original: J:62829 Dobles M, et al., Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 2000 Jun 9;101(6):635-45
• All: 14 reference(s)