Wipf1^tm1Geha
Targeted Allele Detail

Summary

• Symbol: Wipf1^tm1Geha
• Name: WAS/WASL interacting protein family, member 1; targeted mutation 1, Raif S Geha
• MGI ID: MGI:2178802
• Synonyms: WIP-
• Gene: Wipf1 Location: Chr2:73259954-73359831 bp, - strand Genetic Position: Chr2, 43.68 cM
• Alliance: Wipf1^tm1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74719
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 5 of this gene were replaced with a neo resistance gene via homologous recombination. Southern blot confirmed successful targeting of the construct in TC-1 ES cells. Western blot of thymocyte, lymph node, and splenocyte lysates confirmed the absence of protein product in homozygous mutant animals. (J:74719)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wipf1 Mutation: 29 strains or lines available

References

• Original: J:74719 Anton IM, et al., WIP Deficiency Reveals a Differential Role for WIP and the Actin Cytoskeleton in T and B Cell Activation. Immunity. 2002 Feb;16(2):193-204
• All: 13 reference(s)