Sox18^tm1Koop
Targeted Allele Detail

Summary

• Symbol: Sox18^tm1Koop
• Name: SRY (sex determining region Y)-box 18; targeted mutation 1, Peter Koopman
• MGI ID: MGI:2178809
• Synonyms: Sox18-
• Gene: Sox18 Location: Chr2:181311630-181313433 bp, - strand Genetic Position: Chr2, 103.71 cM
• Alliance: Sox18^tm1Koop page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66010
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacing sequences encoding the HMG box with a LoxP-neo-LacZ cassette via homologous recombination. RT-PCR analysis of mutant embryos confirmed transcripts of the HMG coding region were absent although transcripts of the trans-activating domain downstream of the LoxP-neo-LacZ cassette were present. (J:66010)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox18 Mutation: 26 strains or lines available

References

• Original: J:66010 Pennisi D, et al., Mice null for sox18 are viable and display a mild coat defect. Mol Cell Biol. 2000 Dec;20(24):9331-6
• All: 11 reference(s)