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Rev3ltm1Kaji
Targeted Allele Detail
Summary
Symbol: Rev3ltm1Kaji
Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1, Kagemasa Kajiwara
MGI ID: MGI:2178815
Synonyms: Sez4-
Gene: Rev3l  Location: Chr10:39608114-39751207 bp, + strand  Genetic Position: Chr10, 21.04 cM
Alliance: Rev3ltm1Kaji page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74111
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAmino acids 1327 - 1336 of this gene were replaced by a PGK-neo-PolyA cassette via homologous recombination in the orientation of gene transcription. A stop codon engineered into the 5' end of the neo cassette results in the loss of the DNA polymerase domain of the targeted gene. Southern blot analysis confirmed successful gene targeting in ES cells. (J:74111)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rev3l Mutation:  120 strains or lines available
References
Original:  J:74111 Kajiwara K, et al., Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis. Genes Cells. 2001 Feb;6(2):99-106
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory