Rev3ltm1Kaji
Targeted Allele Detail
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Symbol: |
Rev3ltm1Kaji |
Name: |
REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1, Kagemasa Kajiwara |
MGI ID: |
MGI:2178815 |
Synonyms: |
Sez4- |
Gene: |
Rev3l Location: Chr10:39608114-39751207 bp, + strand Genetic Position: Chr10, 21.04 cM
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Alliance: |
Rev3ltm1Kaji page
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Germline Transmission: |
Earliest citation of germline transmission:
J:74111
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Amino acids 1327 - 1336 of this gene were replaced by a PGK-neo-PolyA cassette via homologous recombination in the orientation of gene transcription. A stop codon engineered into the 5' end of the neo cassette results in the loss of the DNA polymerase domain of the targeted gene. Southern blot analysis confirmed successful gene targeting in ES cells.
(J:74111)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rev3l Mutation: |
120 strains or lines available
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Original: |
J:74111 Kajiwara K, et al., Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis. Genes Cells. 2001 Feb;6(2):99-106 |
All: |
2 reference(s) |
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