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Col1a1tm2.1Bst
Targeted Allele Detail
Summary
Symbol: Col1a1tm2.1Bst
Name: collagen, type I, alpha 1; targeted mutation 2.1, Paul Bornstein
MGI ID: MGI:2178816
Synonyms: exon 2delta
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm2.1Bst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73906
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion, Nucleotide substitutions
 
Mutation detailsA floxed PGK-neomycin resistance cassette deleted exon 2 and placed a silent mutation in exon 7. Cre-mediated recombination in vivo removed the neo cassette in the germ line. The authors predict that this allele would produce a correctly spliced protein that lacks 65 amino acids, almost the entire globular domain of the N-propeptide. (J:73906)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  163 strains or lines available
References
Original:  J:73906 Bornstein P, et al., The globular domain of the proalpha 1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice. J Biol Chem. 2002 Jan 25;277(4):2605-13
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory