Wnt3^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Wnt3^tm1Brd
• Name: wingless-type MMTV integration site family, member 3; targeted mutation 1, Allan Bradley
• MGI ID: MGI:2178826
• Synonyms: Wnt3-, Wnt3ⁿ
• Gene: Wnt3 Location: Chr11:103664976-103708783 bp, + strand Genetic Position: Chr11, 67.5 cM
• Alliance: Wnt3^tm1Brd page

Decrease in the number of Dppa3+ primordial germ cells in Ctdnep1^tm1Ryn/Ctdnep1⁺ Wnt3^tm1Brd/Wnt3⁺ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56511
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 and most of exon 4 of this gene was replaced with a puromycin-HPRT cassette via homologous recombination. PCR analysis was used to detect homozygous mutant embryos. (J:56511)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt3 Mutation: 25 strains or lines available

References

• Original: J:56511 Liu P, et al., Requirement for Wnt3 in vertebrate axis formation. Nat Genet. 1999 Aug;22(4):361-5
• All: 12 reference(s)