Arnt2^tm1Yfk
Targeted Allele Detail

Summary

• Symbol: Arnt2^tm1Yfk
• Name: aryl hydrocarbon receptor nuclear translocator 2; targeted mutation 1, Yoshiaki Fujii-Kuriyama
• MGI ID: MGI:2178831
• Synonyms: Arnt2-
• Gene: Arnt2 Location: Chr7:83895486-84059201 bp, - strand Genetic Position: Chr7, 48.35 cM
• Alliance: Arnt2^tm1Yfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74118
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An in-frame NLS-LacZ cassette was introduced into this gene via homologous recombination, disrupting the HLH domain which is involved in dimerization and DNA binding. Successful homologous recombination was confirmed by Southern blotting. Protein was not present in brain of neonate homozygous mutant animals via immunohistochemistry analysis. (J:74118)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arnt2 Mutation: 38 strains or lines available

References

• Original: J:74118 Hosoya T, et al., Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice. Genes Cells. 2001 Apr;6(4):361-74
• All: 1 reference(s)