Jak2^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Jak2^tm1Jni
• Name: Janus kinase 2; targeted mutation 1, James N Ihle
• MGI ID: MGI:2178844
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47299
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The function of this gene was disrupted by replacement of exon 2 with a neomycin resistance gene via homologous recombination. Homozygous mutant embryos were detected by PCR analysis at stage E10-E12. Western blot and immunoprecipitation yielded negative results in E10-E12 homozygous mutant embryos. (J:47299)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 59 strains or lines available

References

• Original: J:47299 Parganas E, et al., Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1;93(3):385-95
• All: 3 reference(s)