Pik3ap1^tm1Kuro
Targeted Allele Detail

Summary

• Symbol: Pik3ap1^tm1Kuro
• Name: phosphoinositide-3-kinase adaptor protein 1; targeted mutation 1, Tomohiro Kurosaki
• MGI ID: MGI:2178861
• Synonyms: BCAP-
• Gene: Pik3ap1 Location: Chr19:41260980-41373541 bp, - strand Genetic Position: Chr19, 34.61 cM, cytoband D1
• Alliance: Pik3ap1^tm1Kuro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75075
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced exon 8 of this gene containing 3 sequences encoding YxxM motifs. Northern blot did not detect gene transcripts in homozygous mutant animals. Western blot of splenic B cells from homozygous mutant animals failed to detect protein product. (J:75075)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3ap1 Mutation: 50 strains or lines available

References

• Original: J:75075 Yamazaki T, et al., Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med. 2002 Mar 4;195(5):535-45
• All: 15 reference(s)