Mdk^tm1Tmu
Targeted Allele Detail

Summary

• Symbol: Mdk^tm1Tmu
• Name: midkine; targeted mutation 1, Takashi Muramatsu
• MGI ID: MGI:2178959
• Synonyms: Mdk-, Mk^-
• Gene: Mdk Location: Chr2:91760149-91762348 bp, - strand Genetic Position: Chr2, 50.63 cM
• Alliance: Mdk^tm1Tmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76278
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 220 bp containing part of exon 1, intron 1 and part of exon 2 was replaced with a neomycin selection cassette. Northern blot analysis on total kidney RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from adult kidney confirmed that no detectable protein was expressed from this allele. (J:76278)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mdk Mutation: 23 strains or lines available

References

• Original: J:76278 Nakamura E, et al., Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells. 1998 Dec;3(12):811-22
• All: 44 reference(s)